- DYDROGESTERONE
Therapeutic Classification : Progestins
Snapshot
Dydrogesterone is synthetic progesterone. Progesterone is a female hormone which is responsible for the healthy growth of the womb (uterine) lining also known as endometrial. If the egg released during the menstrual cycle is not fertilized, progesterone levels decrease and initiates proper shedding of the womb lining (menstruation). If the egg is fertilized and attaches to the womb lining, progesterone levels continue to increase and helps in maintaining the integrity of womb lining which is very necessary to preserve the pregnancy.
Dydrogesterone is used to mimic the action of progesterone in various conditions.
Prescribed in:
- Menstrual disorders: Since the drug supports normal growth and shedding of the uterine lining, it is used for treating menstrual disorders like absent or irregular menstruation, painful menstruation, secondary amenorrhea and premenstrual symptoms.
- Prevent miscarriage: Since the drug helps in maintaining integrity of the endometrial lining in a pregnant womb, it is used for preventing habitual and recurrent abortion.
- Endometriosis: Dydrogesterone relieves the pain during menstruation due to endometriosis without inhibiting ovulation.
- Infertility: The drug is used during IVF (in-vitro fertilization) cycle to achieve successful implantation.
- In combination with hormonal replacement therapy (HRT): Dydrogesterone prevents thickening of the uterine lining in the patient taking HRT.
- TRABECTEDIN
Trabectedin is a tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata.
Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer. It has a role as an antineoplastic agent, a marine metabolite, an anti-inflammatory agent and an angiogenesis modulating agent.